Experience-dependent reorganization of inhibitory neuron synaptic connectivity

We have studied how ongoing experience reorganizes the synaptic connectivity of neurons in the olfactory cortex of the mouse. This revealed that excitatory olfactory neurons with similar odor tuning are more likely to be connected, and inhibitory neurons that responded differentially to repeated encounters with a set of odorants exhibited a high degree of both incoming and outgoing synaptic connections within the cortical network.