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We explore the brain’s circuits and activity
Discovering how information processed by networks of neurons generates our thoughts, emotions, and actions
Scientists at the Neural Dynamics accelerator at Allen Institute analyze and trace the path of signaling in neural circuits cascading across the whole brain and body.
Our approach is focused on how the parts of the brain work together to produce behavior. Teams of researchers develop next-generation neurotechnologies that capture rich data that are shared with the wider scientific community.
We are doing science in the open. Our data and tools are openly available to the community.
We work in a coordinated manner to address complex and deep scientific challenges, leveraging the joint strengths and expertise of diverse scientists and technical staff.
This platform builds on turn-key lightsheet microscopes to image mouse brains at high resolution and throughput. Analysis of the resulting volumetric images, including registration to standard brain coordinates and segmentation and counting of individual neurons, is fully automated.
This platform uses a two-photon microscope SLAP2 that records patterns of synaptic input and output in individual neurons at hundreds to thousands of frames per second in mice performing complex behaviors, using a flexible scan system that combines a digital micromirror device (DMD) with a high-speed scanner.
The Scientific Instrumentation and Process Engineering (SIPE) team is a shared engineering resource within the Allen Institute, focused on enabling and scaling cutting-edge bioscience through integrated hardware and software systems.
This team performs a variety of surgical procedures, including stereotaxic injections and implanting chronic cranial windows and Neuropixels probes.
This platform implements pioneering technology for highly reproducible, targeted, brain-wide, cell-type-specific electrophysiology to record neural activity from defined neuron types across the brain. Analysis and quality control of the electrophysiology data are fully automated.
This platform combines innovative histology, ExA-SPIM microscopy, image handling, and machine learning to map the morphology and molecular identity of individual neurons across the whole brain at high throughput.
This platform enables optical measurement of neural activity and neurotransmitter release in populations of neurons to study neural circuit dynamics in behaving animals.
The Behavior platform uses advanced technology to implement a standardized, modular, multi-task virtual reality gymnasium for mice, with the goal to study brain function across different behaviors at scale.
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We study the biological mechanisms that enable animals to learn the structure of their world through free exploration. To do this, we collect long-term, uninterrupted records of the natural behavior, brain activity, and network connectivity of mice while they repeatedly interact with odors in their environment.
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We are developing and using genetic, electrophysiological, optical, and behavioral approaches to investigate how the brain adaptively controls behavior. The team focuses on understanding the descending circuits that control the execution of actions and how they change when actions are reinforced and refined.
We are using large-scale electrophysiology to study how distributed brain regions coordinate their spiking activity to guide behavior in changing environments.
