Open Tool

Brain-wide neural activity underlying memory-guided movement

Description

Behavior relies on activity in structured neural circuits that are distributed across the brain, but most experiments probe neurons in a single area at a time. Using multiple Neuropixels probes, we recorded from multi-regional loops connected to the anterior lateral motor cortex (ALM), a circuit node mediating memory-guided directional licking.

Projects utilizing this tool

No items found.

Platforms utilizing this tool

No items found.

Platforms accelerate our work

Surgery

This team performs a variety of surgical procedures, including stereotaxic injections and implanting chronic cranial windows and Neuropixels probes.

Multi-Neuropixels Electrophysiology

This platform implements pioneering technology for highly reproducible, targeted, brain-wide, cell-type-specific electrophysiology to record neural activity from defined neuron types across the brain. Analysis and quality control of the electrophysiology data are fully automated.

Brain-Wide Anatomy at Cellular Resolution

This platform combines innovative histology, microscopy, image handling, and machine learning to map the morphology and molecular identity of individual neurons across the whole brain at high throughput.

Fiber Photometry

This platform enables optical measurement of neural activity and neurotransmitter release in populations of neurons to study neural circuit dynamics in behaving animals.

Behavior

The Behavior platform uses advanced technology to implement a standardized, modular, multi-task virtual reality gymnasium for mice, with the goal to study brain function across different behaviors at scale.